What is HAFILLER®?

It is an injectable gel based on stabilized hyaluronic acid of non-animal origin. After gel injection wrinkles are smoothed out, facial contours become clear and you gain a younger and healthy look.

HAFILLER® contour plastic surgery preparations are designed for use in aesthetic medicine as a dermal filler for soft-tissue augmentation, filling and smoothing of skin defects (as in the standard and unconventional areas), deep wrinkles, hypotrophic scars of various origins, correction of involuntary skin ageing.

The preparation is a biphasic sterile pyrogen-free viscoelastic transparent gel based on non-animal stabilized hyaluronic acid. In all products under HAFILLER® trademark concentration of hyaluronate is 24 mg/ml. These products differ in the size of gel particles and field of application of particular filler.

Stabilized non-animal hyaluronic acid that is contained in the HAFILLER® preparations is produced with using biotechnological methods. Natural degradation of stabilized hyaluronic acid in tissues is carried out enzymatically with endogenous hyaluronidase.

When did HAFILLER® appear?

Range of HAFILLER® products was introduced to the world more than 6 years ago and is sold in more than 10 countries worldwide. The range includes:

  • HAFFILER® Fine Lines 1 ml and 2 ml
  • HAFFILER® Derm 1 ml and 2 ml
  • HAFFILER® Derm Deep 1 ml and 2 ml
  • HAFFILER® Derm Plus 1.5 ml
  • HAFFILER® Sub Skin 2 ml

Each filler is designed for application in a particular site. Your doctor will choose the filler, which should be injected, depending on your goals and desires.

About the producer:

Hangzhou Gallop Biological Products Co. Ltd. produces HAFILLER® products. The company specialises in the production of hyaluronic acid for application in such areas as: dermatology, ophthalmology, gynaecology, urology, and orthopaedics. The company firmly got in the market for the production of hyaluronic acid and obtains support from the state, as a company with high-tech developments. The companys staff consists of highly-qualified professionals, scientists, professors, who are constantly improving their developments in the field of hyaluronic acid production and offer innovative products for aesthetic medicine.

Hangzhou Gallop Biological Products Co. Ltd., has introduced in its production processes such global standards of production of medical devices, as
ISO 9001, ISO 13485, CE.

HAFILLER® around the world:

HAFILLER® preparations for contour plastic surgery have been presented in the market of aesthetic medicine for more than 6 years. These products have the highest level of safety, efficacy, prolonged effect and quality. Now the distribution of the range of the products is launched in Russia and the CIS countries. In the same way distribution of the range was launched in countries such as France, Italy, Norway, Syria, Netherlands, Chile, Iran, Colombia, Spain, Brazil, Korea and Panama.

How HAFILLER® is made?

Implant for intra-dermal injection of HAFILLER® series is a sterile, isotonic, pyrogen-free, viscous-elastic clear gel made from highly purified stabilized non-animal cross-linked hyaluronic acid. The hyaluronic acid in HAFILLER® fillers is produced through biofermentation and is recommended for intra-dermal injection in the facial area, for rejuvenation of any skin areas, as well as the correction of age-related changes.

Concentration of sodium hyaluronate in all fillers is 24 mg/ml.

The molecular weight is approximately 10 million Daltons.

How HAFILLER® works?

With ageing, there is a decrease of the hyaluronic acid concentration in the skin. As a result, the skin loses its elasticity and tone. This reduces skin firmness and wrinkles appear. HAFILLER® implant injections into skin tissue restore the extracellular matrix and hydration due to articulated hydrophilic properties of hyaluronic acid. This results in the restoration of skin elasticity and firmness. Small wrinkles are smoothed away and skin looks younger.

Also hyaluronic acid has ability to stimulate collagen synthesis and to bind free radicals, slowing the ageing of skin.

Hyaluronic acid degradation is performed enzymatically with the use of endogenous enzyme hyaluronidase.

HAFILLER® implant is a substitute for endogenous hyaluronic acid in the extracellular matrix, which compensates for losses due to skin ageing. HAFILLER® implant is designed for injection into surface, medium, deep dermis, as well as into the hypodermis.

What are advantages of HAFILLER®?

  • The widest range of products for contouring, consisting of 8 fillers, which will meet your every needs in your daily life.
  • Product use safety (clinical, toxicological, technical testing and certification).
  • Absolute biocompatibility with the human body.
  • The duration of effect (from 7 to 16 months).
  • The ductility and toughness of the drug.
  • Homogeneous distribution in tissues.
  • High levels of patient satisfaction after the procedure.
  • Minor trauma during the manipulation.

Are HAFILLER® products are bio-compable?

The chemical structure of hyaluronic acid is identical, no matter how it was produced. The structure is the same for all species, thus HAFILLER® hyaluronic acid implants do not cause any adverse  reactions related to the incompatibility of the medicine with the body. Exceptions are contraindications for manipulation.

Technology of injection

Injections can be performed by applying the point injection technique or tunnel”uinjection. When using the technique of point injection small amounts of HAFILLER® implant are injected along the contour of the wrinkle with a few separate punctures. When using the technique of tunnel injections”uneedle is held through the puncture along the wrinkle andHAfiller”®fimplant is homogeneously introduced after needle removal.

The choice of technique of injection depends on type and intensity of wrinkles/folds.

It is recommended to use HAFILLER® cross-implant technique in order to treat large areas of the face for optimal anti-ageing effect. The specific technique is chosen according to the area of the skin and the treatment goals.

To prevent the formation of bands one should control that HAFILLER® implant is distributed homogeneously.

Wrinkles that have already been subjected to smoothing do not need to be corrected again. After injecting it is necessary to massage the injection site. It is recommended to cool the injection site for 10 minutes after the procedure.

What is the role of hyaluronic acid?

In the course of time, most people start to notice minor changes in their appearance and begin to wonder – why the skin changes and why is it different from what it used to be?

While some people are well-informed what consequences permanent facial expression, hormonal changes, lifestyle or permanently being in direct sun can lead to, but the others are absolutely unaware of the consequences of neglect to the appearance and importance of hyaluronic acid in modern life.

In the course of time our skin is requiring more cautious and thoughtful attitude. Our body is gradually losing reserves of hyaluronic acid, which is responsible for preservation and maintenance the moisture in our skin. Gradual loss of hyaluronic acid is a result of ageing, negative influence of the environment, unhealthy lifestyle and stress as well.

Hyaluronic acid nourishes our skin and provides/creates certain volume in soft-tissue. Maintenance of moisture, volume and compliance – these are the main components of a young and healthy appearance.

Decrease of hyaluronic acid level and collagen in the body leads to lowering of skin support structure strength, volume of the skin. All these signs of skin ageing lead to soft-tissue sagging and wrinkling. The skin begins to look thinner and less sleek covered with wrinkles and small lines.

What hyaluronic acid is?

Hyaluronic acid is a natural polysaccharide, which is an important building block of skin, subcutaneous cellular tissue, connective cellular tissue, synovial membrane, and also synovial fluid, and is related to a few substances that are chemically identical for all living beings.


What areas can be corrected using the HAFILLER®?

  • Thin wrinkles in the red portion of the lips, as well as marionette folds.
  • Nasolabial folds.
  • Increase of lip shape.
  • Restoration of volume in chin, cheeks.
  • Eye area.
  • Temporal region.
  • Ear lobes.
  • Hand rejuvenation.

How the procedure is performed?

Manipulation with the use of HAFILLER® takes less than one hour and requires minimum time. Treatment time can vary depending on the individual needs and demands of a patient.

Before the manipulation, you can ask absolutely any questions you have, and the doctor should provide you sufficient explanation in all cases.

The initial step before gel injection is:

Getting a complete patient history in order to detect any contraindications for hyaluronic acid gel injection.

Preliminary examination the areas which are desired to be corrected, as well as establishing the possibility of correction of the area.

Signing of informed consent forms for carrying out a manipulation of this type (it is attached to the patient records, where information about following corrections and precautions after the manipulation is also indicated).

The next step is the preparation of the injection area. The doctor should clean and disinfect the area into which the preparation is to be injected. Then, a process of anaesthesia is carried out (local anaesthesia, blockade anaesthesia). The anaesthesia method selection is individual, the doctor chooses the method of anaesthesia, which is acceptable and which suits a particular area of gel injection best. Each zone has its own pain limit during implant injection, thus the choice of anaesthesia is quite individual and is selected by the direct medical examination before the manipulation.

What to avoid before manipulation?

Avoid the usage of aspirin, non-steroidal anti-inflammatory drugs (such as ibuprofen), tutsan, as well as large doses of vitamin E. These components of these preparations may prolong healing of bruises, and also cause more prolonged bleeding at the site of the gel injection.

It is obligatory to tell your doctor about how often you have had symptoms of herpes outbreaks. A few days before the procedure, the doctor may prescribe you to use medicine that will reduce the risk of herpes recurrence.

What is recommended to observe and to do after the procedure?

  • Apply a cold compress to the site of injection in order to reduce swelling.
  • Avoid touching the site of injection during the first 6 hours after the manipulation in order not to hurt the skin, which is very sensitive after the gel injection. 6 hours after the manipulation, you can gently wash the injection site with soap and water.
  • Avoid severe temperature differences, such as exposure
    to heat (e.g. solarium or being in direct sun) and to cold.
  • During the week after the manipulation, avoid use of aspirin, non-steroidal anti-inflammatory drugs, tutsan, as well as a higher dose of vitamin E. The components of these medicines may increase bruising.

Are there any adverse reactions and what are the symptoms after the procedure?

Structure of hyaluronic acid contained in HAFILLER® fillers is identical to the one of hyaluronic acid in the body. Therefore HAFILLER® fillers are biocompatible with the human body and do not cause an adverse reactions. If all precautions are taken and history is taken properly, HAFILLER® fillers do not cause an adverse reaction. Temporary symptoms after the procedure are: redness, swelling, and mild pain at the injection site, itching, temporary discoloration of the skin at the injection site, increased sensitivity in the gel injection site.

Immediately after the injection redness and swelling can appear. Reactions connected with the injection may disappear spontaneously in a short time. Rarely at the injection site one can notice bands and swelling, which disappear within 2-4 weeks. In rare cases, there is itching and skin discoloration.

Allergic reactions develop very rarely, as HAFILLER® implant is identical to the hyaluronic acid of the human body. In the case of an inflammatory reaction, the patient is recommended to consult a doctor, who will decide whether any treatment is necessary.

How long does the effect last?

If all the requirements after the procedure are followed, the effect can last up to 16 months, depending on the filler and an area subject to correction.

If you want to prolong the effect of the manipulation, you can sign up for additional correction.

This correction will let you keep the original result for 3 years. This means that at a certain time you have to come to your doctor to carry out a slight correction. Correction requires a small amount of HAFILLER® gel injection.

Such correction every few months will let you maintain the initial effect and always look great.

You can get a plan for the further correction and effect prolongation from your doctor. Drafting of the plan is an individual process and is made in private, depending on peculiarities of correction area and your wishes.

When can I see the results after the manipulation?

Immediately after the manipulation, you will notice a positive change in your appearance. You will notice a more natural look after the swelling and redness at injection site reduces.

How much gel should be injected into a specific area?

Amount of the gel injected into a specific area is decided immediately before the procedure by doctor only.

What information should be provided to a doctor before the manipulation?

Immediately before the procedure, you should tell your doctor if there are any chronic or autoimmune diseases, outbreaks of allergies of any kind lately. You also need to tell if you have problems with blood circulation.

Are there any contraindications?

Contraindications for the use of HAFILLER® implants for counter plastic surgery are:

  • Pregnancy and lactation period.
  • Allergic reactions to hyaluronic acid.
  • The presence of autoimmune diseases and during immunotherapy, psoriasis.
  • Severe skin infections (herpes, acne, dermatitis).
  • Coagulation defects and a tendency to scarring.
  • HAFILLER® implants should not be administered into: blood vessels, joints, breasts or muscles.
  • The presence of anaphylactic reactions in the patient’s record.
  • The presence of permanent filler in the site of gel injection.
  • The presence of any other chronic diseases incompatible with the use of HAFILLER® implants for contour plastic surgery.

In order to avoid unwanted consequences after administration of HAFILLER® contour plastic surgery products you need to make sure in advance, that the manipulation is conducted by a certified physician with the medical education in this field in the special place to carry out such manipulation, with the presence of all the standard documentation providing the right to conduct medical services in a specially designated place, namely the presence of a medical license.

In the same way, to ensure that your expectations match the quality of the manipulation performed you should provide the physician with full information about your medical history and allow the specialist to take this history efficiently.